Resolved. Had to re-install 4.0 manually, then had to use my old .htaccess file. Not the one listed in the documentation.
RewriteEngine On
RewriteBase /
#uploaded files
RewriteRule ^(.*/)?files/$ index.php [L]
RewriteCond %{REQUEST_URI} !.*wp-content/plugins.*
RewriteRule ^(.*/)?files/(.*) wp-includes/ms-files.php?file=$2 [L]
RewriteRule ^(.*/)?avatar/(.*) wp-content/avatar.php?file=$2 [L]
# add a trailing slash to /wp-admin
RewriteCond %{REQUEST_URI} ^.*/wp-admin$
RewriteRule ^(.+)$ $1/ [R=301,L]
RewriteCond %{REQUEST_FILENAME} -f [OR]
RewriteCond %{REQUEST_FILENAME} -d
RewriteRule . - [L]
RewriteRule ^([_0-9a-zA-Z-]+/)?(wp-.*) $2 [L]
RewriteRule ^([_0-9a-zA-Z-]+/)?(.*\.php)$ $2 [L]
RewriteRule . index.php [L]
The file doesn’t get uploaded to the directory wp-content/blogs.dir/7/files…
Neither does it get uploaded to wp-content/uploads…
Yes the url structure has not changed.