My issue was due to the fact that some code was left over from when my site was under development which pointed to the WP_Super_Cache plugin that was missing. I installed this plugin and edited the wp-config.php file where I found this offending line:
define ‘WPCACHEHOME’, wrong place //Added by WP-Cache Manager
which I changed to point the right place on my hosting platform.
Problem fixed!
Ever since WordPress update 4.5 this error occurs intermittently without any apparent rhyme or reason. Would appreciate some guidance to get past this on-going annoying problem. My hosting provider Hostgator has been consulted about this problem and they believe this has something to do with WordPress.
