Hey, thanks for responding to my admittedly vague question. 🙂
This isn’t my site, but it’s a good example, since it works well on both desktop and mobile: http://www.mrlovenstein.com/
Ignore all the ads, I’m not looking to do that right now. I’m looking for the clean presentation of comic image along with the navigation. The header, footer, and side column I understand how to implement and know gp can do. The archive seems simple enough as well. But, I’m wondering if I’m going to be pulling my hair out trying to shoehorn a comic into the gp content area, whether I use the Comic Easel plugin or not.