Yes I have 7 WPML languages activated and that is the cause why the settings are not saved…
The problem in my case was that the settings form had over 1000 fields. In php.ini the default limit of post.max_vars is default 1000 and because of that the form nonce and action were not submitted. I would like to ask Marcus to consider splitting the settings form in smaller sections, one for each tab (general, emails, etc.) in the new version of the plugin.