WordPress URL Prefix / PermaLinks / MultiSite

I’m working on the WordPress infrastructure of our site, want to do the following:

• http://domain.com => Main Site (lang: EN), Pages only
• http://domain.com/nl/ => Main Site (lang: NL), Pages only
• http://domain.com/support/ => Support Site, Pages only
• http://domain.com/blog/ => Blog, mainly Posts, few Pages
• http://domain.com/anotherblog/ => Another type of Blog w/ different template, mainly Posts, few Pages

The question is, what would be the best setup for this infrastructure?

• Can this be done using PermaLinks (don’t see this happen in standard WP Settings > Permalinks?)?
• OR is it better to just use separate WP installs?
• OR should we use the WP MultiSite feature (http://codex.wordpress.org/Create_A_Network)
• OR should we do something completely different?

Hope you can give some advice, thanks!

[Moderator Note: No bumping, thank you.]