Sorry, I did not see this when you posted it, but to be honest, I don’t know, I’ve never used it. This plugin caches data using the WP transients API.
To answer this question, after doing some research, there is no reason that this plugin should not work with memcached.
Although, I’m not sure that this plugin will increase the speed of a site that is already using memcached. From what I’ve read memcached will store the cache for longer periods so adding this plugin on top of that may just create extra work that is never used.
The only time that the addition of this plugin would be useful is if the cache expiration set up in this plugin is longer than the expiration time of memecached. Otherwise you’ve done an extra DB query to store an object in the database that will be expired by the time it’s ever needed again.
