Latest version update

I am trying to update my wordpress account tothe latest version. Everytime I try I get this error message.

Downloading update from http://wordpress.org/wordpress-3.5.2-partial-1.zip…

Unpacking the update…

Warning: copy(/homepages/46/d298644532/htdocs/app469642075/wp-admin/includes/update-core.php) [function.copy]: failed to open stream: Permission denied in /homepages/46/d298644532/htdocs/app469642075/wp-admin/includes/class-wp-filesystem-direct.php on line 200

Could not copy files.

Installation Failed

I have tried switching themes, but that doesn’t work. I have had no issues with updates on any of my other wordpress sites, just this one.

Regards

Charles