Different look for different pages?

I am trying to update this site and translate it into WP. It requires different sections to have completely different looks. Is this possible without having to create a responsive theme from scratch?

http://www.atlanticliners.com

Specifically the following pages:

http://www.atlanticliners.com/onaseaofglass/
(and its sub-page) and…

http://www.atlanticliners.com/theunseenmauretania/
(and its future sub-pages).

I want to be able to use a theme for the primary bulk of the site, but as you can see, certain pages need to have a different appearance. I am trying to re-design this site for mobile-friendly, but now I’m not sure if WP is the best possibility? Any suggestions greatly appreciated.