I did this with a website I run. I wanted to use wordpress for the content management aspects. I found a template that was simple, and was similar in sturcture to the website theme I already had and then hacked away at the css and the individual pages to make them do what I wanted and lay out the way I wanted.
http://www.mixedstudentresources.com
ladydelaluna – This is exactly what I needed. Thanks for posting