I too have an issue where certain users seem to be unable to load my podcast… at first I thought it was because I was using the .m4a extension… so I changed the .m4a to .mp3… and still some users had problems.
However, when I am the one trying to replicate the this problem… I can’t repeat it… I can always get it to work (have tried XP, Mac OSX, and even Vista). What I did notice was that in Vista, it loads the entire file before it will play… and opens in itunes… so my first episode was 60 some megabytes, which meant I had to wait for all 60mb to be downloaded before it played.
I use a link to the file in my post (ex: domain.com/podcast/ep1.mp3).
Hope this helps and if you find out more, let me know too.
my site is djmoose.ca