Hi there,
You mean the first byte of a minified and combined asset?
This is expected when combined assets are minified for the first time. For all the gory details please see: http://betterwp.net/wordpress-minify-javascript-css/
Before posting I read carefully what is written in the link. I also searched the forum and did some research via google, but nothing. The problem in my case is that the delay is always presented and not only the first time that the files are created. You have a system to send one screnshot? Otherwise you can check, for example, directly at link blog.rodigarganico.info
Does this happen when you disable friendly minify url feature?
“Enable friendly Minify urls” is active. If the disable it, the waiting time greatly improves, even if in some cases is still high.
Then it has something to do with your server’s setting (httpd.conf or .htaccess file) when handling static assets.