Dividing the loop among different cells

I’m working on a news blog and wants to add a bit of newspaper style to the display of posts, using different styles for the headlines on various parts of the front page, as for example is done on http://www.timesonline.com where one headline is bigger than the others.

I need help on how to divide the loop into several little chunks that I can paste in the relevant cells of the first page columns, but still hanging together so that the posts are being pushed downwards. (As is often done on http://www.resume.se where the main headline column presents a couple of headlines, divides into two sub-columns that display news and then becomes one column again.

Naturally, I also don’t want the post to be duplicated. Also, the posts are not from any particular category but the general feed.