The plugin, if implemented correctly, should be compliant with WCAG 2.1. However, I’m not willing to provide guarantees, as interference from the theme or other plugins can introduce accessibility problems. I also can’t guarantee that every possible combination of options will result in a compliant interface; there are just too many possibilities for me to be confident I’ve tested them all.
If you use category identifiers (available as colors and as icons), you need to use the icon option to maintain full compliance, as otherwise the only identification of categories on the main view is color alone.
You also should not use the legacy disclosure widget popups for the mini calendar view or the grid view. Though that’s not much of a concern, since they’re going to be removed in version 3.8, which will ship fairly soon.
Additionally, My Calendar is developer with a strong accessibility-first ethic, so if you do identify concerns, they are always prioritized in development.