WP e-Commerce + thematic + Simplecart = an amazing job. I have got this working on a number of test sites.
It is a stunning theme that was made for the WP e-Commerce Plugin. If all you've got time to do is pick holes in WP e-Commerce (here as opposed to the instinct forums) you need to find a better hobby.
I would bet my little finger that Chris Wallace is a more experienced theme designer then you - so if it is good enough for Chris then it is certainly good enough for 99% of the WordPress community.
Thanks again to Chris for his hard work!!
(and a big boo to people that just complain and never contribute)