I upgraded to WP 2.5 yesterday. There were minor hiccups, but things seem to have mostly proceeded without hitch.
However, there seems to be an issue with comments. When I get an email to approve a comment and access it from the links there I can see them, and they show up both on the dashboard and in the context of a post, but not from the comment tab in the admin interface. Any ideas? I tried disabling the sezwho plugin, but that didn't seem to have an impact.