With my site hitting 5,000 posts, I thought I should work with the look and ad placement without making the site look to much out of touch with to many ads.
With out using any plugins, I created some custom scripts which depending on the size of the post, ads are placed in the blank areas. I'm working with about 24 different ad sizes. There are some areas I still need to look at, but I think I got what I was looking for. Any feedback would help a lot on any problems or other ideas you may have.