This is an awesome plugin, it rocks.
My site is Multi-site, sub-domain, multi-databases, buddypress, bbpress, domain mapping option,and much more!
The only problem I've found is when making a group page is the visual editor is offset to and over the right sidebar when using Firefox browser. It works looks fine when using chrome. The visual editor works just appearance is awkward.
I tested it as super admin and sub-domain site admin on both browsers.