I've spent all week working on making my site faster and more efficiently served. I've employed a number of techniques and a few plugins. Out of the gate Total Cache offered to do all of these things for me, but what I quickly realized is that I was far better off tackling each item individually. And at the end of the day, this plugin didn't offer me any one thing valuable enough to justify it's use.
I suppose it might work for someone that wants to "set it and forget it" but really if that is your approach to web site optimization, you aren't likely to be very successful. I'm not even sure this plugin would even work for that crowd (despite the fact that it is recommended by Media Temple - of which I am a happy customer). The configuration options are overwhelming. I went through every option and again at the end of the day I'm much better off looking at each optimization technique individually.
For those interested, I'm doing everything myself with the exception of two fantastically helpful plugins. Better WP Minify and WP Super Cache. Each was simple to setup and focused on a particular need.