First of all Transposh is a great plugin! It works fantastic and solves some big issues that other plugins have left.
I have a blog that has become quite large (over 1000 users, 5000 participants) and it is across many countries and its content is international. http://www.prepareforchange.net
My website does have a problem when activating this plugin because it gets caught in a redirect loop after an hour or so of activity. I can fix this problem temporarily by clearing the caches ((Purges everything: The page-cache, the CDN cache, and the object cache)
However within a few hours the site will get caught in a redirect loop again and I have to flush it once more.
I have read the FAQ pages on the plugin site and found the threads relative to it but the fixes to the plugins/themes don't apply to my situation.
Here are a list of my plugins
better menu widget
cleantalk spam protect
comment disable master
cudazi scroll to top
facebook featured image and open graph meta tags
gravity forms - multi-lingual
gravityforms user registration
lightbox pop - not activated
page links to
sitepress multilingual cms - not activated
youtube embed plus
WPML - old translation program (has been deactivated)
I also have set up a mirror site in a staging area that is non-cached according to my host. I have noticed that the redirect loop does not happen there.
http://prepareachange.staging.wpengine.com/ (you can login with the same details from above.
Additionally I have a dedicated WordPress Host called WP Engine.
They have told me that in order to solve the problem once I have spoke with the developer that they can adjust their server settings to best suit the site and plugin configuration.
I would really appreciate some help with this as I have really tried everything within my own abilities.
Once again this is a great plugin!