Spaminator now has an user interface, so that you can make configuration changes on the fly. If you completely screw things up, you can remove the config settings and go back to the hardwired defaults (which are pretty good, BTW).
But the big news is:
Kitten's Regex Service
If you're confused by the regular expressions (regexes) needed to keep blocking the latest spam, help is only a click away!
In the Spaminator config page click the "Get Regexs" button, and you'll get the latest info from my site, that you can then copy & paste into the Spaminator's regex boxes.
In one click you'll have the same settings that I use to protect my blog. But it's dependant upon the settings of your webhost's php install. So it might not work for you, if this is the case, you'll get a message telling you where you can see the info.
I hope this makes your spam fighting a little more tolerable.
(You'll need to be running a nightly later than Jan 5th to use this)