Only having recently switched to Safari for some browsing I noticed that Quicktags were missing. A quick search revealed that Safari had problems with Quicktags so they were disabled.
Intrigued I removed the browser check and tested each tag I have ... there was nothing wrong. Safari handled them fantastically.
Exactly what is the supposed problem? I'm using Safari 2.0.2 and WordPress 1.5 (not sure how to check exact version number).