Quite a lot of support threads we respond to are duplicates, or have the same steps to debug and resolve. Please follow these steps before posting a topic.
Ensure you're using the latest version of the plugin.
Try switching to the 2011 or 2012 theme, we have tested Meta Slider with about 15 free themes, we are unable to test with premium themes.
If it is working with the default 2011 or 2012 theme but not your premium theme, then you should contact your theme developer for help.
If you're making the theme yourself then ensure your theme has both the wp_header and wp_footer functions in the correct places.
Read through the support forum, it is likely that your question has already been answered.
Try switching to a different slider library in the slideshow settings.
If none of the above solve your issue, please post a topic and we will be glad to help. Please ensure your include:
A URL to your site where the slider is not working
The version of Meta Slider you are using
Any error messages you are seeing
The browser you are using
Any more details that might be helpful, eg it works when I X but not when I X..
Confirmation that you have followed the above steps