Honestly, I was skittish about using this plugin to manage my podcast, but gave it a shot anyway. It works much, much better than I had expected. It was easy to set up, easy to get connected with iTunes, and with 50+ episodes already, have not had any issues.
The part that I love best is that you really do have solid control over how things appear in iTunes. You make any changes to your posts, and they are reflected in iTunes.
I'm hosting my podcast media with Amazon S3, and it has been seamless, reliable, and easy.
Looking forward to seeing where this plugin goes from here.