Recently saw that there was an update for YouTube with Style from v7 to v8. I upgraded the plugin and activated it only to find a completely blank site with literally no code being thrown at the browser from the web server.
It did not result in a 500 error either, literally just resulted in... Nothing. Disabling the plugin solves the issue and I rolled back to v7.
I do have WP-Minify and WP-Supercache installed.