We have a problem with SuperCache clearing all cache files for all blogs on our multisite install when anyone posts, I've made sure that the "Clear all cache files when a post or page is published or updated." is unticked globally, and checked it on other blogs to concur. $wp_cache_clear_on_post_edit = 0; is also set in wp-cache-config.php. Am I missing something or is this default behaviour? Pages are only currently caching for a few seconds between people posting.
I'm not overly bothered as we cache with Varnish too, but I find caching with Super Cache first makes the pages a lot faster and is also a backup if the Varnish cache is cleared.