Currently, I run nginx configuration as Nginx recommends – really simple and default setup with "try_files $uri $uri/ /index.php?q=$uri&$args;" to enable pretty URL's in WordPress. My website is working fine with this settings (nginx + W3TC + Xcache + Varnish) for a long time, and today I found your plugin.
I see that in your set up tutorials (http://rtcamp.com/wordpress-nginx/tutorials/) you recommend using WordPress + Nginx + fastcgi_cache. As it's the first time I read about fastcgi_cache and have no experience with it, my question is:
-> May I try that combination (WordPress + Nginx + fastcgi_cache + this Nginx Helper Plugin) for best performance? This is also keep working fine with any PHP opcode (like APC or Xcache) and Varnish?