it's tough to not want to tear the author a big one here, because this plugin works great when running a default WP install. But if you try to move wp-content directory, ( as described here: http://codex.wordpress.org/Editing_wp-config.php#Moving_wp-content, watch out.
Recommended: reduce or clarify the defines found in the main plugin file. It's impossible for even a skilled programmer to figure out what all of this stuff is used for, without dissecting the entire plugin.
This plugin needs to be re-worked on that basis alone, there's no reason for it to not be portable.