restore your old .htaccess (that you should always save before installing such a plugin)
otherwise edit .htaccess, the WP better Sec. parts are separated.
If you want to retry, Then do not enable WPSec all options at once, but one at the time.
I agree with what Peter said.
One of my developer clients had the same problem with the latest version of the plugin. After restoring a copy of the .htaccess file generated by an older version of the plugin, his client's site is back up and running.
I should note that this is a temporary fix at best, even if the settings for the plugin aren't changed. Without a thorough inspection of the plugin's code and a fix for the issue, there's no telling what might happen moving forward.
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