We just had an issue where an iframe reload resulted in the page being scrolled to the bottom. It's apparently a common issue with iframes that have internal navigation and can be pretty confusing as the user has to scroll up to find the content.
The solution was hacking advanced-iframe.php so that
<iframe ... was now
This was at about line 212. It's less than ideal and it would be nice to have an option in the admin page to toggle this setting...