I know this is supposed to be a support forum but I just had to gush about NoSpamNX. It's been my only spamproofing on lee.org for 6 months now and it's worked exceptionally.
I set wordpress to moderate unknown user comments
I installed NoSpamNX
I set the NoSpamNX Local Blacklist to block "http://" and "https://"
I removed the URL field from my comment interface
I put a note in my comment file telling users "Do not write “http://” in your comment, it will be blocked."
I still have to moderate new user comments but this is easy and I want to watch my blog comments anyway. The amount of spam I have to review from the moderation cue is very at 1-5 per week. On rare occasions, I enable the blocking of specific strings like "win free sex now" to stop some comment spam bots (I think I've done that 3 times in 6 months). NoSpamNX has been blocking 200-1,000 comment spams per day for a long while now.
Hurray and huzzah! Thank you!