I just had this come in via email. It's not related to Optimizer (rather a conflict with another plugin), but thought I'd post it in case it helps someone out...
The user's site had NextGEN Gallery properly configured, with one album containing two galleries correctly set up. This was being called on a WordPress Page with the [album id=1 template=compact] shortcode which displayed as expected.
However, when we clicked either of the two galleries displayed, the page would reload (with "album=1&gallery=1" query string parameters attached to the URL as normal), but the gallery would not display, and there was zero HTML output in the source from NextGEN.
While it's uncertain exactly which plugin caused the conflict in this case, the problem did resolve itself after disabling all plugins (except NextGEN Gallery and Optimizer). After enabling them all again one-by-one (to spot the source of the trouble), we found all plugins were able to be reactivated without breaking the album gallery pages again (though do check them individually as your situation may differ).
Hope this helps!