There's never any content when you click on S3, it just says the folder is empty. Clicking the back button seems to activate the back button of the browser, taking you to the last page you were on in the site, not the last place you were in the media manager.
Also, it seems to interfere with other plugins who add options to the Media Manager. We utilize Brightcove video cloud which adds an option underneath the S3 link. When I click on it, for some reason I get the S3 plugin interface stating that there is nothing in the folder. After clicking on Brightcove and it becoming active, mousing over any of the links shows the S3 url, not a BC one.
Example: Upload, Home, etc all link to http://chicagophoenix.com/wp-admin/media-upload.php?chromeless=1&post_id=19511&tab=tantan-wordpress-s3&prefix