Upgrading a client from 2.8.4(I think) to 2.9. Plugins were left activated. (I came after the error - just sayin'). Twitip added over 70,000KB of data to the database. Took down her host server. Unfortunately, I don't know enough to confirm if this is a one-off thing. Perhaps nothing to do with that plugin... not sure.
If there's anything I can do to help confirm this issue, let me know.