I have SpamKarma2, Bad Behavior and Askimet installed. I've got that sk2_pjw_moderate plugin, too.
I blacklisted words in my WordPress discussion options that are supposed to send spammy commments directly to moderation.
I even forced my commenters to do a "preview-first" before they are allowed post a comment.
Yet the spam keeps on coming. It's for phentermine, for viagra, for poker, for insurance, for hot teenage incestuous lesbians with big butts—and somehow it's getting past all my force fields.
I'm running out of ammo, guys. The spam is about to start chowing down on my brains! Outside of turning off my comments, what should I do?