Is it possible to go straight to CDN bypassing any writes to wp-content?

I’ve got a situation in which I’m running a WordPress installation in which I’m disallowing WordPress to write to the server. I’d like to be able to use some of the uploading capabilities in the media manager. I’m wondering if anyone has had any luck connecting directly to a CDN (ie. Amazon S3) to manage media files (wp-content) bypassing any writes to the server?

In a practical situation I’d like to emulate the capabilities of W3 Total Cache’s CDN integration (uploading/syncing to S3/Cloudflare etc.) without the need to write to the server.

I already realize there will be some issues with the image libraries, and resizing, thumbnailing, etc.., but if anyone has done something similar or know of a plugin that’s been known for this capability, I’d love to hear about it.