I'm running 2.2.1 right now. For some reason, my blog works fine in Firefox and Netscape but IE freezes for about 30 seconds when it loads. I've tried disabling all plugins, but that doesn't help. I've switched themes, but it doesn't help. And I tried to rerun the upgrade, but that still doesn't help.
Check it out:
I don't know what else to do.
Once it does load in IE, you can reload the page and it's fine. But if you open a new browser (of IE) then it will hang again.