The new layout of the write/edit post in 2.5 isn't as efficient as before. The text area is narrower than the before and all the options like categories, authors, comments/ping, tell-a-friend form (cformsII plugin) and passwords have been moved under the text area, leaving a big blank white column on the right-hand side and requiring a long scroll-down to enter the custom fields, All-in-One SEO pack and meta data.
I preferred the old layout with all those options on the right-hand side.
Otherwise, everything looks good. Takes some getting used to, but very nice. :)