I see that currently this plugin has an array of hotfixes for each specific WordPress version. I worry about the behavior of opting folks into each and every hotfix for their version instead of just the specific one that affects them, especially since a "hotfix" is released out of the normal testing and support cycle.
Personally, I think this plugin might work better if it provided a checkbox in admin to opt in to individual hotfixes for issues that affect them. Otherwise I think a lot more people are likely to enable this plugin, forget about it, and then get a lot of fixes that don't get the usual vetting and testing.
Just my two cents, I do really like the central idea of this plugin and think it can make WordPress a lot more useful for folks with a minimal amount of updating overhead.