That depends...do you want the lightbox effect? Or do you want the reader to be taken to a specific post when they click on the image/text?
If they're going to a specific post, you can just use a custom loop and some custom CSS styling.
Something like this....
<?php query_posts('cat=23&posts_per_page=20&paged='.$paged); ?>
<?php if (have_posts()) : ?>
<?php while (have_posts()) : the_post(); ?>
<a href="<?php the_permalink(); ?>"><img class="video_page_thumb" src="<?php video_thumbnail(); ?>" />
<?php the_title(); ?></a>
<?php endwhile; ?>
<?php endif; ?>
That's what I used on this page.
All you'd have to do is add a template tag in the loop for the_excerpt() if that's what you wanted as a description. Then you could use the manual excerpt box in the post editor screen to create the description text.
Just a thought. Hopefully that helps a little.