I was using two separate plugins to keep my database optimized. When I switched to a multisite layout, the two plugins didn't do what I wanted them to do and broke the site recently (had backed everything up, so no major headache there). Then, I stumbled upon WP-Optimize. Not only can I network activate this plugin and manage each site individually, but I was able to "fire" those other two plugins and replace them with this one.
Great work, love it, will be buying you a big coffee soon. =8^)