With this plugin you can make beatiful slideshows with many options.
However a lightbox functionality is actually not implementet. The Author says it will come with version 2.3. With a small workaround it is possible to have a lightbox now.
The plugin is uses the media libary of wordpress.
I really like it. I have testet several plugins and this one fits best to my needs.
And the best is, it's free. There is no Pro version. So you can test it and then donate a small fee.
I'm looking forward to the next vesion!