Same situation here—just upgraded to 2.2 as well: website
I use the default Kubrick theme with some very minor mods in a seperate css file—nothing that would cause this sort of problem.
Lucida Grande is looking bad in the dashboard as well.
For what it’s worth I think I’ve narrowed down the cause of the problem, and it probably isn’t WordPress in my case—importing the MySQL database, as I switched hosts at the same time as upgrading, and text encoding are probably to blame.
As for the dashboard, cleaning the font caches on my mac has solved that.
I do however know another WP blogger who experienced the same issue during a Fantastico control panel upgrade to 2.2.
Right, does anyone actually read these support forums? There is a known error, and here is one solution for it.
I myself fixed it an even harder way—exporting my WordPress database and then using a text editor to find and replace all the garbled punctuation.
