Different editions of site by city

I don’t know if anyone could help me out, but what would be the best way to create a site with different editions for different cities? I need to have different content on each different city page and also different advertisements.

I have thought about making the cities different categories but I don’t know if I would be able to control the advertising that way. I also thought about doing every city as a page and then using a get post plugin to put posts on pages.

Here is a site that is similar to what I want to do, does anyone know how they did it?