I upgraded to 2.6.1 using the auto-upgrade plugin last night. Everything is great except comment moderation. I cannot see the previous 1900+ comments, nor do new comments show up. The only way I can moderate is to find the post in which the comment was made and moderate it manually. The icon on the comments page tells me there is new comments, but when I click on it, it tells me there are no comments to moderate yet. All 1900+ old comments do show up in their respective posts so it seems to be only the comments moderation page that is not functioning properly.
Also, it will not allow me to remove spam. In this case I can see the spam comments, unlike regular comments, but it doesn't matter how many times I click the delete spam button they do not go away. This is also located on the comments moderaton page.