Choosing a Framework Theme

Hey! I’m in the process of working on the main landing page for my site and I’m a little overwhelmed with the amount of choices for frameworks to start creating a theme with. What I don’t want to do is spend a long time on one theme only to get brickwall’d finding out that It doesn’t really work for what I’m going for. So if you could make some suggestions for me or tips it would be greatly appreciated! A link to what look we’re kind of going for is: http://cupofcomics.com/images/mockup.png

It’s a fairly old mockup, but for what the site is currently looking like: http://cupofcomics.com

Thanks!