Can you add the cleaning by Clean-Up which is more efficient than that of WP-Optimize?
Before answering anything, try and see that clean-up cleans better.
First try cleaning with wp-optimize and see for clean-up, there is still dirt.
I use clean-up every day and it has never caused any problems.
clean-up is very efficient in 33 lines of PHP code with a very convenient dashbord widget.