I don't know if anybody else has as much interest in this as I do, But:
I switched back to Twenty Eleven from an open-source Framework because I couldn't figure out how to get things done the way that I wanted them. This is not a complaint but strictly a desire. It may be that I don't have the programming skills of quite a few others here, so I'm just winging it.
I've been trying to learn how Mobile Responsive Design has evolved, and have installed most of the following WordPress Plugins into my site:
Can the core Developers of WordPress embed these capabilities, scripts, whatever you want to call them, into the next or following version of WordPress? The most difficult of them seems to be the last one http://adaptive-images.com/. I had to reduce my former 3-column layout to Twenty-Eleven's 2-column in order to get my site to be presentable on Smart Phones and some Feature phones. I disabled the WPtouch plugin http://wordpress.org/extend/plugins/wptouch/ since it's theme didn't present my site the way that I wanted it to be seen (this is not a complaint against their developers either).
I would like to have a great 3-column layout (with multiple Header Images) for Desktop viewing, and then some Responsive capabilities to step it down to 2-column for Tablets, and then 1-column for Smart Phones. Better yet, how about a WordPress core built from the ground Up (1-column Mobile, 2-column Tablet, 3+ column Desktop)?
The idea is to alter the WordPress Core so that as few plugins as possible are necessary to achieve Responsive Design Layouts. I wonder if it would be easier to build from the Top Down (http://Boston.com), or would it be easier for WordPress core Developers to restructure from the ground Up (Mobile First) http://stuffandnonsense.co.uk/projects/320andup/ ?