Wow, I tried installing this wp-super cache plugin on my site http://www.teleread.org/blog/ with high hopes. I'm using 2.2.2
It seemed to be a bit faster. but it created blank pages whenever users made comments or posts.
For making posts, we could live with blank pages, but not comments.
When I tried removing/deactivating it, it deactivated, but now the wp site is even slower than before I installed it.
I have no idea why this is happening. This is quite painful.
Suggestion: provide instructions about a safe way to bring the site to a state before wp-super cache was installed.