All theme layouts fail…

…except Twenty Ten. I’ve been using the Twenty Ten theme for 3 years, keeping my blog on a back page and not using it much. Now I’m trying to turn it into my main page, to display online comics. I tried for hours to set up ComicPress, but the page always showed all the content lined up along the left side, with an ugly TimesRoman font. I tried Webcomic (with the Inkblot theme) and Stripshow, but had other major issues with both. Two frustrating days later I found that every theme I activated came up with all the content smooshed against the left side, except the original Twenty Ten. I’ve re-installed WordPress twice, and deactivated all the themes and plug-ins so many times I’ve lost count. Is this a lost cause? Am I doomed?