For some odd reason and I know this was an issue with earlier releases of Akismet but it seems to persist. When I active the plug in with the API and all, it crashes the server. After a little while I can access the server but anytime I try to access plugins it takes me to a "server side" 404 page. Even after I deactivate it, for some time I get the dreaded 404. And it doesn't matter what page I try to access the 404 will simply reference that page.
By the way, tried reinstalling it manually through FTP.